Dissertation On Nanorobotics

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Doctoral Thesis

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  1. Magnetically Driven Multifunctional Nanorobots for Biomedical Applications 

    The work presented in this dissertation focuses on the design and development of novel, multifunctional and magnetic nanorobots for applications in the field of medicine. Minimally invasive and targeted biomedical procedures will greatly benefit from the progress made in nanotechnology. In this context, the doctoral work aims to address current medical challenges and presents novel therapeutic approaches, by combining the merits of ...
  2. Three-Phase PFC Rectifier and High-Voltage Generator for X-Ray Systems 

    Medical X-ray systems have been under steady development since the discovery of X-rays by R¨ongten in 1895. However, the principle of X-ray generation has remained the same. Electrons are accelerated within an evacuated tube by a high-voltage difference from the cathode towards the anode. X-rays are emitted when electrons hits the anode. However, most of the energy of the electrons is dissipated by the anode in form of heat. Therefore, ...
  3. Efficient Numerical Optimal Control for Motion Planning and Control of Mobile Robots 

    Robotics holds high promises contributing solutions to our future society's challenges by taking over dangerous, physically intense work or fill up the lack of skilled labor resulting from population aging. To fulfill these promises, robots will need to solve increasingly complex tasks, requiring more versatile hardware designs with more degrees of freedom. Paired with fast development cycles, this poses a major challenge for robotic ...
  4. Visualization Methods for Simulation-based Natural Disaster Risk Assessments of Road Networks 

    Infrastructure managers are in charge of ensuring that infrastructure provides an acceptable level of service to society. To evaluate whether such a level of service can be maintained in the case of natural disasters, a generic risk assessment process was developed in the INFRARISK project. This process accounts for the complex interactions between a multitude of spatio-temporal systems, which may ultimately lead to negative impacts ...
  5. Asymptotic Inference in Sparse High-dimensional Models 

    Janková, Jana(2017)
    High-dimensional data with a sparse structure occur in many areas of science, industry and entertainment. Diverse applications motivated the need to devise efficient statistical methods for analyzing high-dimensional datasets. While methodology for point estimation is elaborate and generally well understood, in many applications it is essential to quantify statistical uncertainty by providing a confidence interval, a p-value or a test. ...
  6. Community dynamics and transmission within the Phialocephala fortinii s.l. - Acephala applanata species complex 

    Just about all plants are colonized by fungal endophytes. Dark septate endophytes (DSE) are a diverse group of ascomycetes colonizing roots of a vast number of plants in many different ecosystems. Considering the Northern hemisphere, the majority of DSE belong to the Phialocephala fortinii s.l. - Acephala applanata species complex (PAC), consisting of at least 21 morphologically indistinguishable cryptic species (CSP), to seven of which ...
  7. Individuality and Collective Behavior in Bacterial Populations 

    Individuality and collective behavior are two terms that the general public might not readily associate with bacteria, yet both concepts have become central in recent studies of bacterial populations. Bacteria in clonal populations share the same genetic information, yet they can differ substantially in their phenotype. This is partly due to cells adapting their phenotype to local environmental differences. However, the stochastic nature ...
  8. Diversity, Accessibility and its Impact on Vehicle Ownership and Residential Location Choices 

    van Eggermond, Michael A.B.(2017)
    The research objectives of this thesis are twofold. The first objective is to contribute to the measurement of the built environment and the subsequent relationship between the built environment and transport and land-use related decisions by individuals. On one hand there exists the need to describe, measure and design the built environment; on the other hand there is the economist's perspective, that takes interest in what individuals ...
  9. New Tools for Engineered Networks of Neurons 

    Aebersold, Mathias J.(2017)
    The brain is a fascinating structure to investigate not only because of its staggering complexity but also because of its clinical importance. The human brain consists of more than 80 billion nerve cells, each receiving up to 10000 input connections. Despite big efforts in neuroscience, we still do not understand how the brain carries out its basic functions, such as information processing and storage, because the critical link between ...

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Robotics has markedly extended the reach of human beings in sensing, manipulating, and transforming the world around us. One of the most inspiring challenges in science and technology is to extend our capacity with tiny robots towards operations at the micro/nanoscales, a dimension where we can directly interact with fundamental biological building blocks. This thesis is devoted to advancing micro/nanorobotics to extend human being’s capacities in following three themes, with a special focus being given to biomedical applications. The first theme focuses on design and fabrication of bio-inspired un-tethered nanorobots with efficient locomotion, adaptive operation, collective regulation, and eventually biological function towards operation in whole blood. The second theme explores the versatility of functional micro/nanorobots to perform diverse tasks including writing (nanolithography), reading (superresolution imaging), destroying (warfare agents), and repairing (surface cracks), all at the micro/nanoscale. The third theme employs self-propelling microrobot as an active delivery technique that autonomously and precisely transports the therapeutic agents inside live animal’s gastrointestinal tract, improving therapeutic efficacy for bacterial infection treatment. This technique opens the door for micro/nanorobots as an active delivery platform for medical treatment and is promising for a wide range of personalized diagnostic and therapeutic applications. Ultimately, micro/nanorobots has the potential to change the game of science, engineering, and medicine by extending our capacity at the micro/nanoscale. The novel applications presented in this thesis are just a few examples showing the power of micro/nanorobots, with countless more avenues waiting to be explored towards living and active matter, and eventually artificial intelligence and synthetic life at the micro/nanoscale.

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